Table of Contents:
Preface to the Sixth Edition
Reference
Chapter 1. Introduction
Intended Learning Outcomes
What Are Viruses?
Are Viruses Alive?
The History of Virology
Living Host Systems
Cell Culture Methods
Serological/Immunological Methods
Ultrastructural Studies
Molecular Biology
Further Reading
Chapter 2. Particles
Intended Learning Outcomes
The Function and Formation of Virus Particles
Capsid Symmetry and Virus Architecture
Helical Capsids
Icosahedral (Isometric) Capsids
Enveloped Viruses
Complex Virus Structures
Protein–Nucleic Acid Interactions and Genome Packaging
Virus Receptors: Recognition and Binding
Other Interactions of the Virus Capsid with the Host Cell
Summary
Further Reading
Chapter 3. Genomes
Intended Learning Outcomes
The Structure and Complexity of Virus Genomes
Molecular Genetics
Virus Genetics
Virus Mutants
Genetic Interactions between Viruses
Nongenetic Interactions between Viruses
Small DNA Genomes
Large DNA Genomes
Positive-Strand RNA Viruses
Negative-Strand RNA Viruses
Segmented and Multipartite Virus Genomes
Reverse Transcription and Transposition
The Virome—Evolution and Epidemiology
Summary
Further Reading
Chapter 4. Replication
Intended Learning Outcomes
Overview of Virus Replication
Investigation of Virus Replication
The Replication Cycle
Summary
Further Reading
Chapter 5. Expression
Intended Learning Outcomes
Expression of Genetic Information
Control of Prokaryote Gene Expression
Control of Expression in Bacteriophage λ
Control of Eukaryote Gene Expression
Genome Coding Strategies
Transcriptional Control of Expression
Posttranscriptional Control of Expression
Summary
Further Reading
Chapter 6. Infection
Intended Learning Outcomes
Virus Infections of Plants
Immune Responses to Virus Infections in Animals
Viruses and Apoptosis
Interferons
Evasion of Immune Responses by Viruses
Virus–Host Interactions
The Course of Virus Infections
Prevention and Therapy of Virus Infection
RNA Interference
Viruses as Therapeutics
Chemotherapy of Virus Infections
Summary
Further Reading
Chapter 7. Pathogenesis
Intended Learning Outcomes
Mechanisms of Cellular Injury
Viruses and Immunodeficiency
Virus-Related Diseases
Bacteriophages and Human Disease
Cell Transformation by Viruses
Cell Transformation by Retroviruses
Cell Transformation by DNA Viruses
Viruses and Cancer
New and Emergent Viruses
Zoonoses
Bioterrorism
Summary
Further Reading
Chapter 8. Subviral Agents: Genomes without Viruses, Viruses without Genomes
Intended Learning Outcomes
Satellites and Viroids
Prions
Pathology of Prion Diseases
TSE in Animals
Human TSEs
Molecular Biology of Prions
Summary
Further Reading
Appendix 1. Glossary and Abbreviations
Appendix 2. Classification of Subcellular Infectious Agents
Appendix 3. The History of Virology
Index
