Fifty million people worldwide have epilepsy and yet up to 35% of patients experience seizures that are resistant to anti-epileptic drugs. Patients with medication-resistant epilepsy have increased risks of premature death, psychosocial dysfunction and a reduced quality of life. This key resource delivers guidance for all clinicians involved in caring for patients with medication-resistant epilepsy in order to reduce these risks. Covering the epidemiology, biology, causes and potential treatments for medication-resistant epilepsy, this definitive and focused text reviews the clinical care needs of patients. Guidance is practical and includes treatment for specialized groups including pediatric patients and those with psychiatric comorbidities. Several promising non-pharmacologic interventions available for patients, such as surgery, neuromodulation diet therapy and botanical treatment are explored in detail. Leading international figures from a range of disciplines bring their expertise together holistically in this essential manual.
Focuses on the clinical care needs of patients, making it an essential guide for practicing clinicians
A broad yet detailed scope allows for the entire text to be read, bringing together topics holistically in an accessible handbook format
Treatments covered are cutting-edge, with the latest research and evidence discussed in detail meaning clinicians will be able to make fully informed decisions for their patients' care
Contents
1. The natural history of epilspy Byugin Lee and Sung-Eun Kim
2. Challenges in identifying medication-resistant epilepsy Martin J. Brodie and Pauls Auce
3. International league against epilepsy's definition in medication-resistant epilepsy Colin B. Josephson and Samuel Wiebe
4. The economic impact of medication-resistant epilepsy Charles E. Begley and Shin Jeong
5. Social consequences of medication-resistant epilepsy Amy Crepeau and Joesph I. Sirven
6. Morality and morbidity of medication-resistant epilepsy Nuria Lacuey and Samden D. Lhatoo
7. Models for medication-resistant epilepsy Raman Sankar
8. Neurobiology of medication-resistant epilepsy Jerome Engel Jr
9. Genetic causes of medication-resistant epilepsy Thomas N. Ferraro, Bradford D. Fischer and Russel J. Buono
10. Malformation of cortical development as causes of medication-resistant epilepsy Ruben Kuzniecky
11. Hippocampal sclerosis as a cause of medication-resistant epilepsy Fahmida Amin Chowdhury, Beate Diehl and Maria Thom
12. Autoimmune causes of medication-resistant epilepsy Anteneh M. Feyissa and Jeffrey W. Britton
13. Medication-resistant epilepsy syndromes in children Elia M. Pestana Knight and Elaine Wyllie
14. Medication-resistant epilepsy in adults Martin Holtkamp and Felix Benninger
15. Approach to the treatment of medication-resistant epilepsy John Stern
16. Pharmacotherapy for medication-resistant epilepsy Graham A. Powell and Anththony G. Marson
17. Reproductive health for women with medication-resistant epilepsy Jiyeon Yoo and Cynthia Harden
18. Resective medication-resistant epilepsy surgery Barbara C. Jobst and Krzyszof A. Bujarski
19. Ablative surgery for medication-resistant epilepsy Christian Hoelscher, Kofi-Buaku Atsina, Chengyuan Wu and Ashwini Sharan
20.1. Vagus and trigeminal nerve stimulation treatment of medication-resistant epilepsy George Nune and Christianne Heck
20.2. Electrical stimulation of the anterior nucleus of the thalamus for medication-resistant epilepsy Mohamed Z. Koubeissi and Amr Ewida
20.3. Responsive neurostimulation of the brain for medication-resistant epilepsy Ritu Kapur and Martha J. Morrell
20.4. Stimulation treatments for medication-resistant epilepsy: transcranial magnetic stimulation Lara M. Schrader
21. Diet therapy for medication-resistant epilepsy Eric H. Kossoff and Daniel B. Lowenstein
22. Botanical treatments for medication-resistant epilepsy Steven C. Schachter
23. Psychiatric comorbidities in medication-resistant epilepsy Andres M. Kanner.
