Atlas of Peripheral Blood

This book will be a full-colour atlas of both benign and neoplastic proliferations in the blood. The book will illustrate the morphologic features on peripheral blood smears of the various disorders and the text will focus on diagnostic criteria, differential diagnosis and modern classification terminology. The book may be used as a stand-alone resource and should be useful to trainees and clinicians that routinely review peripheral blood smears. The book will be accompanied by an on-line image bank containing numerous additional full-color images of the various disorders. Irma Pereira MT (ASCP), SH, Clinical Hematology Specialist, Clinical Laboratories, Stanford University, Stanford, CA Tracy I George MD, Assistant Professor of Pathology, Director, Clinical Hematology Laboratory, Stanford University Medical Center, Stanford, CA Daniel A Arber MD, Professor and Vice Chair of Pathology, Medical Director, Anatomic Pathology and Clinical Laboratory Services, Department of Pathology, Stanford University, Stanford, CA CONTENTS Preface Contributors * Chapter 1 Introduction (Including smear methods, staining, features of the normal blood smear and the approach to interpretation) Section 1 Red Blood Cells and Their Disorders * Chapter 2 Common Red Cell Changes/Nomenclature (Targets, Schistocytes, Spherocytes, etc) * Chapter 3 Anemia Due to Abnormal or Impaired Hemoglobin Synthesis * Defects in iron metabolism * Defects in porphyrin synthesis * Defects in globin chains, including thalassemias * Chapter 4 Anemia Dues to Abnormal or Impaired DNA Synthesis * Anemias with oval macrocytosis * Megaloblastic Anemia * Myelodysplastic Syndrome * Congenital dyserythropoietic anemia * Anemias with round macrocytosis * Reticulocytosis * Liver disease * Alcoholism * Chapter 5 Hemolytic Anemias * Extracorpuscular * Microangiopathic anemia * Oxidative hemolytic anemia * Autoimmune hemolytic anemia * Heat-associated and other traumatic anemias * Intracorpuscular (Membrane defects) * Congenital spherocytosis * Congenital ovalocytosis * Pyropoikilocytosis * Hemolytic Ovalocytosis * Congenital Acanthocytosis * a-betalipoprotinemia * Acquired Acanthocytosis * Alcoholic cirrhosis * Liver disease/tumors * Anorexia nervosa * Prematurity * Unstable hemoglobins Section 2 Granulocytes and Their Disorders * Chapter 6 Reactive Changes in Granulocytes and Monocytes * Chapter 7 Systemic Disorders with Granulocyte and Monocyte Inclusions * Chediak-Higashi granules * May Hegglin anomaly * Mucopolysaccaridosis/Alder Reilly granules * Morquio syndrome * Hurler syndrome * Wiskott Aldridge syndrome * Chapter 8 Chronic Myeloproliferative Disorders * Chronic myelogenous leukemia * Chronic phase * Accelerated phase * Blast phase * Polycythemia vera * Chronic idiopathic myelofibrosis * Essential thrombocythemia * Chronic neutrophilic leukemia * Chronic eosinophilic leukemia and hypereosinophilic syndrome * Mast cell disease * Chronic myeloproliferative disorders, unclassifiable * Chapter 9 Myelodysplastic Syndromes and Related Entities * Myelodysplastic features in the blood * Pelger-Huet anomaly * Drug effects mimicking myelodysplasia * Chapter 10 Myeloproliferative/Myelodysplastic Diseases * Chronic myelomonocytic leukemia * Atypical chronic myeloid leukemia * Juvenile myelomonocytic leukemia * Mixed myeloproliferative/myelodysplastic disease, unclassifiable * Chapter 11 Acute Myeloid Leukemia * AML, not otherwise categorized subtypes * AML with t(8;21) * AML with inv(16) * Acute promyelocytic leukemia (AML with t(15;17) and variants) * AML with other cytogenetic abnormalities * AML with multilineage dysplasia * Therapy-related AML and myelodysplasia * Chapter 12 Acute Leukemia of Ambiguous Lineage * Acute undifferentiated leukemia * Biphenotypic acute leukemia * Bilineal acute leukemia Section 3 Lymphocytes and Their Disorders * Chapter 13 Reactive Lymphocytes * Infectious mononucleosis * Others (other viral infections, large granular lymphocytes and pertussis) * Chapter 14 Precursor Lymphoid Malignancies * Precursor B-lymphoblastic leukemia * Precursor T-lymphoblastic leukemia * Chapter 15 Mature Small B-cell Neoplasms Involving the Blood * Chronic lymphocyte leukemia * Usual Type * Atypical CLL Abbreviated Table of Contents