Myeloma

Myeloma is the second-most common hematologic cancer, accounting for approximately 1 percent of all cancers and 2 percent of all deaths from cancer. In recent years there have been major and significant advances in the diagnosis, imaging, molecular pathogenesis, and therapy of myeloma. This book describes these advances in a single, practical volume, placing them in the context of daily clinical practice. Different myeloma subtypes are discussed in individual chapters, integrating etiology, pathogenesis, molecular pathology, histology, and therapy in a single place for each condition. The book begins by discussing epidemiology, imaging techniques, pathogenesis, and other general considerations. Conditions covered in detail include multiple myeloma, POEMS syndrome, Castleman's syndrome, Waldenstrom's macroglobulinemia, amyloidosis and MGUS. Featuring color illustrations, and written and edited by leading authorities in the field, Myeloma provides readers with the information they need to diagnose and manage these complex disorders. Diagnosis, treatment and management of a condition are discussed in a single chapter, giving readers all of the relevant information in one place Each chapter is written by a leading expert in the field and a wealth of clinical experience is shared with the reader Color illustrations accompany the text to aid understanding Stephen A. Schey, Department of Haematology, King’s College Hospital, London Kwee L. Yong, Department of Haematology, University College Hospital, London Robert Marcus, Department of Haematology, King’s College Hospital, London Kenneth C. Anderson, Dana-Farber Cancer Institute, Boston Table of Contents Preface Part I. Overview of Myeloma: 1. Epidemiology of myeloma Eve Roman and Alexandra G. Smith 2. Diagnosis and immunophenotyping of myeloma Roger Owen 3. Imaging of myeloma Nicola Mulholland and Ming Wan Part II. Biological Basis for Targeted Therapies in Myeloma: 4. Cell cycle regulation and myeloma precursor cells John Quinn and Kwee L. Yong 5. The genetic and epigenetic mechanisms underlying the behaviour of myeloma Martin F. Kaiser, Kevin D. Boyd and Gareth J. Morgan 6. The myeloma bone marrow environment and survival signaling Kwee L. Yong, John Quinn and Asim Khwaja 7. Immune dysfunction in multiple myeloma Guy Pratt and Paul Moss 8. Myeloma bone disease: pathogenesis of bone destruction and therapeutic strategies Andrew Chantry and Neil Rabin 9. Principles of pathway directed therapy for myeloma Yu-Tzu Tai and Kenneth C. Anderson Part III. Myeloma: Clinical Entities: 10. Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma Efstathios Kastritis and Meletios A. Dimopoulos 11. Multiple myeloma: management of de novo disease T. Guglielmelli, P. Sonneveld, A. Broyl and Antonio Palumbo 12. Treatment of relapsed/refractory myeloma Matthew J. Streetly, Jacob Laubach, Paul Richardson and Stephen A. Schey 13. Solitary bone and extramedullary plasmacytoma Shirley D'Sa 14. Amyloidosis Ashutosh D. Wechalekar, Simon W. Dubrey and Raymond L. Comenzo 15. Waldenstrom's macroglobulinemia/lymphoplasmocytic lymphoma Steven P. Treon and Giampaolo Merlini 16. Castleman's disease Karthik Ramasamy 17. POEMS syndrome and paraproteinaemic syndromes: management and follow-up Angela Dispenzieri and Suzanne R. Hayman Part IV. Supportive Therapies: 18. Treatment of emergent peripheral neuropathy and plasma cell disorders Charise Gleason, Melanie Watson and Sagar Lonial 19. Management of renal failure in multiple myeloma Aneel Paulus, Pooja Advani, Nabeel Aslam and Asher Alban Chanan-Khan 20. The management of infection in myeloma Christopher P. Conlon Index.