The Sperm Cell

This revised and updated second edition provides a comprehensive account of the human male gamete. Detailed overviews of human sperm production, maturation, and function - and how these processes affect and influence fertility, infertility, and assisted reproduction - are given. A wide range of new developments including proteomics, spermatogenesis, sperm-specific WW domain-binding proteins, Ca2+ signalling, DNA packaging, epididymis are explored, whilst a new chapter presents information gained from mouse genetics, highlighting how it informs male fertility research. The impact of environmental factors during pre-pubertal and pubertal stages of life is also investigated. Featuring engaging prose with chapters organized topographically, The Sperm Cell remains an essential resource for andrologists, clinical scientists, and laboratory personnel.

    This expanded new edition includes compelling new information from the fields of epigenetics, proteomics and genetics
    Summarizes many unique and revealing aspects about testicular and sperm function for the reader's clarity
    Presents information gained from research using mice as a model for understanding human gamete function

Table of Contents

List of contributors
Foreword Ryuzo Yanagimachi
Preface
1. Spermatogenesis: clinical and experimental considerations Ellen Goossens and Herman Tournaye
2. Sperm chromatin stability and susceptibility to damage in relation to its structure W. Steven Ward
3. Sperm ultrastructure in fertile men and male sterility: revisiting teratozoospermia Hector E. Chemes
4. Sperm RNA and its use as a clinical marker Meritxell Jodar, Ester Anton and Stephen A. Krawetz
5. Role of the epididymis in sperm maturation Robert Sullivan and Clémence Belleannée
6. Seminal plasma plays important roles in fertility Susan S. Suarez and Mariana F. Wolfner
7. Physiological and pathological aspects of sperm metabolism Zamira Gibb and Robert John Aitken
8. Regulation of sperm behaviour: the role(s) of [Ca2+]i signalling Stephen Publicover
9. Proteomics of capacitation Mark A. Baker
10. Current concepts and unresolved questions in human sperm cumulus and zona interaction Christopher De Jonge and Christopher L. R. Barratt
11. Sperm specific WW-domain binding proteins Richard Oko, Mahmoud Aarabi, Jiude Mao, Hanna Balakier and Peter Sutovsky
12. Fundamental role for sperm phospholipase C zeta at mammalian fertilization Michail Nomikos, Karl Swann and F. Anthony Lai
13. Genetic basis of male infertility Amin S. Herati, Peter R. Butler and Dolores J. Lamb
14. The Sperm epigenome Timothy G. Jenkins and Douglas T. Carrell
15. Environmental factors and male fertility Tina Kold Jensen, Hanne Frederiksen, Katrine Bay and Niels E. Skakkebaek
16. Male infertility and assisted reproduction Nigel Pereira, Queenie V. Neri, Tyler Cozzubbo, Stephanie Cheung, Zev Rosenwaks and Gianpiero D. Palermo
17. Mouse genetics - how does it inform male fertility research? Laura O'Hara and Lee B. Smith
18. Susceptibility of the testis to lifestyle and environmental factors during the life course Richard M. Sharpe
Index.

Christopher J. De Jonge, University of Minnesota
Christopher De Jonge is Director of the Andrology Program at the University of Minnesota Medical Center and Adjunct Professor in the Department of Urology at the University of Minnesota.

Christopher L. R. Barratt, University of Dundee
Christopher L. R. Barratt is Professor of Reproductive Medicine at the School of Medicine, University of Dundee, Ninewells Hospital, Dundee.
Foreword

Ryuzo Yanagimachi, University of Hawaii, Manoa
Contributors

Ryuzo Yanagimachi, Ellen Goossens, Herman Tournaye, W. Steven Ward, Hector E. Chemes, Meritxell Jodar, Ester Anton, Stephen A. Krawetz, Robert Sullivan, Clémence Belleannée, Susan S. Suarez, Mariana F. Wolfner, Zamira Gibb, Robert John Aitken, Stephen Publicover, Mark A. Baker, Christopher De Jonge, Christopher L. R. Barratt, Richard Oko, Mahmoud Aarabi, Jiude Mao, Hanna Balakier, Peter Sutovsky, Michail Nomikos, Karl Swann, F. Anthony Lai, Amin S. Herati, Peter R. Butler, Dolores J. Lamb, Timothy G. Jenkins, Douglas T. Carrell, Tina Kold Jensen, Hanne Frederiksen, Katrine Bay, Niels E. Skakkebaek, Nigel Pereira, Queenie V. Neri, Tyler Cozzubbo, Stephanie Cheung, Zev Rosenwaks, Gianpiero D. Palermo, Laura O'Hara, Lee B. Smith, Richard M. Sharpe