Essential Endocrinology and Diabetes

Essential Endocrinology and Diabetes provides the accurate and up-to-date knowledge required for treating all areas of endocrinology and diabetes, covering the latest research, clinical guidelines, investigational methods, and therapies. This classic text explains the vital aspects of endocrine physiology in a succinct and easy-to-use format, with full-colour illustrations, clinical images, and case studies to assist readers in applying theory to practice.

The text covers the principles of endocrinology, clinical endocrinology, and clinical diabetes and obesity, and has been revised throughout to present the most recent developments in the field. The seventh edition includes new and updated material on the latest molecular techniques, approaches to clinical investigation and diagnostics, next generation sequencing technology, and positron emission tomography (PET). The treatment of type 1 diabetes and type 2 diabetes has been updated with clinical algorithms and reflects significant advances such as incretin-based therapies, SGLT2 inhibitors, the development of better insulins, and technologies that support self-management.

    Provides students and practitioners with comprehensive and authoritative information on all major aspects of endocrine physiology
    Covers diagnosis, management, and complications of clinical disorders such as endocrine neoplasia, and type 1 diabetes and type 2 diabetes
    Explains the core principle of feedback regulation, which is vital for the correct interpretation of many clinical tests
    Features case histories, learning objectives, ‘recap’ links to chapter content, cross-referencing guides, key information boxes, and chapter summaries

Essential Endocrinology and Diabetes, Seventh Edition is the ideal textbook for medical and biomedical students, junior doctors, and clinicians looking to refresh their knowledge of endocrine science.

Contents

Preface vii

List of abbreviations x

How to get the most out of your textbook xii

PART 1: Foundations of Endocrinology 1

1 Overview of endocrinology 3

2 Basic cell biology and hormone synthesis 14

3 Molecular basis of hormone action 27

4 Investigations in endocrinology and diabetes 48

PART 2: Endocrinology – Biology to Clinical Practice 63

5 The hypothalamus and pituitary gland 65

6 The adrenal gland 99

7 Reproductive endocrinology 127

8 The thyroid gland 165

9 Calcium and metabolic bone disorders 190

10 Pancreatic and gastrointestinal endocrinology and endocrine neoplasia 213

PART 3: Diabetes and Obesity 233

11 Overview of diabetes 235

12 Type 1 diabetes 257

13 Type 2 diabetes 285

14 Complications of diabetes 311

15 Obesity 343

Index 360

Richard Holt is Professor in Diabetes and Endocrinology at the University of Southampton, UK, and Honorary Consultant in Diabetes at University Hospital Southampton NHS Foundation Trust. 

Neil Hanley is Professor of Medicine at the University of Manchester, UK, and Honorary Consultant in Endocrinology at the Manchester University NHS Foundation Trust.