Inflammatory Bowel Diseases: A Clinician’s Guide provides practical guidance for the diagnosis and management of those suspected or known to have one of the forms of these complex diseases. It is perfect both for gastroenterology trainees learning to care for these patients and the experienced physician as a concise and practical resource for day to day use.
Written by the experts, Inflammatory Bowel Diseases: A Clinician’s Guide is an essential tool for all gastroenterologists managing patients with inflammatory bowel disease.
Contents
Foreword
Preface
Section I – Pathogenesis and Clinical Features
Chapter 1: Epidemiology and Pathogenesis
Epidemiology
Pathogenesis
Genetics
Microbiome
Environment
Chapter 2: Clinical Features and Diagnosis of Crohn’s disease
Clinical features
Natural history
Diagnosis
History and physical examination
Laboratory investigations
Serologic markers
Endoscopy
Imaging
Chapter 3: Clinical Features and Diagnosis of ulcerative colitis
Clinical features
Natural history
Diagnosis
History and physical examination
Laboratory investigations
Serologic markers
Endoscopy
Imaging
Differential diagnosis
Chapter 4: Extra intestinal Manifestations of IBD
Arthritis and Arthropathy
Cutaneous manifestations
Hepatobiliary disease
Ophthalmologic manifestations
Renal manifestations
Thromboembolic and cardiovascular risk
Section II – Therapeutic Agents
Chapter 5: Aminosalicylates
Efficacy in Ulcerative colitis
Efficacy in Crohn’s disease
Safety
Chapter 6: Corticosteroids
Efficacy in Ulcerative colitis
Efficacy in Crohn’s disease
Safety
Chapter 7: Immunomodulators
Thiopurines
Efficacy in Ulcerative colitis
Efficacy in Crohn’s disease
Safety
Methotrexate
Efficacy in Ulcerative colitis
Efficacy in Crohn’s disease
Safety
Calcineurin inhibitors
Efficacy in ulcerative colitis
Efficacy in Crohn’s disease
Chapter 8: Biologics
Infliximab
Efficacy in Ulcerative colitis
Efficacy in Crohn’s disease
Safety
Adalimumab
Efficacy in Ulcerative colitis
Efficacy in Crohn’s disease
Certolizumab pegol
Efficacy in Crohn’s disease
Golimumab
Natalizumab
Vedolizumab
Newer Therapies
Chapter 9: Antibiotics
Efficacy in Ulcerative colitis
Efficacy in Crohn’s disease
Other microbial modification methods – probiotics and fecal microbiota transplantation
Section III - Management
Chapter 10: Medical Management of Ulcerative colitis
Assessment of extent, activity, and severity
Limited colitis – proctitis, proctosigmoiditis, and left-sided colitis
Pancolitis
Mild to moderate disease
Moderate to severe disease
Severe disease
Chapter 11: Medical Management of Crohn’s Disease
Mild to moderate disease
Moderate to severe disease
Chapter 12: Surgical Management of Inflammatory Bowel Diseases
Surgery for ulcerative colitis
Pouch-related complications in ulcerative colitis
Surgery for Crohn’s disease
Prophylaxis for prevention of postoperative recurrence in Crohn’s disease
Chapter 13: Complications of IBD
Complications of ulcerative colitis
Toxic megacolon and perforation
Colonic Strictures
Clostridium difficile and cytomegalovirus colitis
Colorectal dysplasia and cancer
Complications of Crohn’s disease
Fibrostenosis and strictures
Abscesses
Fistulizing Crohn’s disease
Small bowel cancer
Section IV – Special Considerations
Chapter 14: Nutrition in IBD
Malnutrition and micronutrient deficiencies
Dietary Therapies for IBD
Chapter 15: Pregnancy, Conception and Childbirth
Fertility
Effect of pregnancy on disease
Effect of disease on pregnancy
Maternal Medication use during pregnancy
Paternal Medication use
Inheritance
Chapter 16: Inflammatory bowel disease during childhood and adolescence
Epidemiology and clinical features
Treatment of pediatric IBD
Very early onset IBD
Transition of Care
References
Index
Ashwin N Ananthakrishnan MD, MPH, Co-Director, Crohn’s and Colitis Center, Massachusetts General Hospital, Assistant Professor of Medicine, Harvard Medical School, USA
Ramnik J Xavier, MD, Chief, Gastrointestinal Unit, Director, Center for the Study of Inflammatory Bowel Disease, Kurt Isselbacher Professor of Medicine, Harvard Medical School, USA
Daniel K Podolsky, MD, President, Professor of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA
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